I've been playing around with the noise reduction in Lightroom 3 for a couple days, and I'm reasonable impressed. I shot this image last night around 1:00 a.m. in lighting conditions I usually think of as unusable. I bumped the ISO on my old 20D up to 3200 and shot this at f2.8 with a 1/5 sec image-stabilized shutter. The image is a little soft, but I'd say it's usable. Maybe it's not ideal, but I think I'm more willing to shoot super-high ISO if absolutely necessary.